Hepatotoxicity after Sevoflurane Exposure in a Patient with Chronic Hepatitis C

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Nickul N Shah*
Nina Ballone
Raul Zamora
Peter DeVito
Samuel Wilson

Abstract

Sevoflurane is considered a safe inhaled anesthetic of choice in patients with liver disease. Compared to other halogenated inhaled anesthetics, Sevoflurane is reported to lessen the severity of decreased hepatic blood flow and undergoes a different mechanism of hepatic metabolism. In patients with preexisting liver disease, there is potential for low-flow Sevoflurane to induce acute liver damage through other mechanisms. Limited data exists to guide clinical decision-making when quantifying the severity of cirrhosis in patients with hepatitis C and its relationship to anesthesia choice. Previous studies have found that exposure to general anesthesia during abdominal surgery may increase the risk of hepatorenal failure. This study has raised a concern that anesthetics may interfere with various hepatic functions secondary to viral infection. The generation of abnormal liver enzymes and hypercoagulation has provided further exploration for such toxicity.

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Article Details

Shah, N. N., Ballone, N., Zamora, R., DeVito, P., & Wilson, S. (2015). Hepatotoxicity after Sevoflurane Exposure in a Patient with Chronic Hepatitis C. Global Journal of Medical and Clinical Case Reports, 2(1), 023–027. https://doi.org/10.17352/2455-5282.000021
Case Reports

Copyright (c) 2015 Shah N, et al.

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