Myxoid Leiomyosarcoma of the Uterus in a Fertile Woman
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Abstract
A 37 year old woman (G1P1 spontaneous delivery) was admitted to our university hospital for menometrorrhagia. The case history showed the patient had menometrorrhagia for six months; moreover, during the abdominal examination we found a mass occupying the hypogastric and mesogastric area. The consistence was hard and the mass reached the level of the umbilicus. The combined vaginal-abdominal examination confirmed the presence of the mass on the anterior wall and, in addition, multiple myomata were felt; the uterus was found enlarged in size (equivalent to 18 pregnancy weeks); both ovaries and Fallopian tubes were regular. During surgery multiple myomata were visualized. The largest, 10 centimeter diameter, was soft in consistence with a gelatinous structure. Total abdominal hysterectomy with preservation of adnexa was performed.
Histopathological result gave evidence of myxoid leiomyosarcoma for the largest myoma, whereas the other nodes were benign.
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Carlo P, Vito L, Antonio C, Gianluca L, Grazia SM, et al. (2011) Efficacy evaluation of a test CINtec® p16INK4a in screening for cervical HPV infection. Open Journal of Preventive Medicine1: 154-163. Link: https://goo.gl/zstbRH
Pafumi C, Iraci SM, Abbate G, Clemente CM, La Rosa I, et al. (2010) Protection of ovarian tissue from radiotherapy. Bratisl Lek Listy 111: 443-448. Link: https://goo.gl/UW0fhv
Zarbo G, Giunta MR, Giannone TT, Pafumi C, Leanza V (2014) Correlazione tra HPV e adenocarcinoma dell’endocervice. Gazzetta Medica Italiana. Archivio Per Le Scienze Mediche 173: 259-264. Link: https://goo.gl/LnYIwk
Leanza V, Fichera S, Leanza G, Cannizzaro MA (2011) Huge fibroid (g. 3.000) removed during cesarean section with uterus preservation. A case report. Ann Ital Chir 82: 75-76. Link: https://goo.gl/9LiIhM
Leanza V, D’Agati A, Accardi M, Russo ER (2009) Multiple myomectomy performed during cesarean section: a case report. Minerva Ginecologica 61: 245. Link: https://goo.gl/Cpnawy
Tse KY, Crawford R, Ngan HY (2011) Staging of uterine sarcomas. Best Pract Res Clin Obstet Gynecol 25(6): 733-749. Link: https://goo.gl/AMJQfn
Christopherson WM, Williamson EO, Gray LA (1972) Leiomyosarcoma of the uterus. Cancer 29: 1512-1517. Link: https://goo.gl/aRrvFE
Rubin BP, Fletcher CD (2000) Myxoid leiomyosarcoma of soft tissue, an underrecognized variant. Am J Surg Pathol 24: 927-936. Link: https://goo.gl/6fTMZj
Chang E, Shim SI (1998) Myxoid leiomyosarcoma of the uterus: a case report and review of the literature. J Korean Med Sci 13: 559-562. Link: https://goo.gl/4aQIxj
Hendrickson MR, Kempson RL (2000) A diagnostic approach to smooth muscle tumours of the uterus. Curr Diagn Pathol 6: 21–30 Link: https://goo.gl/1APRvc
Oliva E, Clement PB, Young RH (2002) Mesenchymal tumours of the uterus: selected topics emphasizing diagnostic pitfalls. Curr Diagn Pathol 8: 268–282 Link: https://goo.gl/6qapGz
Burch DM, Tavassoli AF (2011) Myxoid leiomyosarcoma of the uterus. Hystopathology 59: 1144-1155 Link: https://goo.gl/osoQS1
Szabó I, Szánthó A, Csabay L, Csapó Z, Szirmai K, et al. (2002) Color Doppler ultrasonography in the differentiation of uterine sarcomas from uterine leiomyomas. Eur J Gynaecol Oncol 23: 29-34. Link: https://goo.gl/vyLMb5
Toledo G, Oliva E (2008) Smooth muscle tumors of the uterus: a practical approach. Arch Pathol Lab Med 132: 595-605 Link: https://goo.gl/CcbG6H
Sung CO, Ahn G, Song SY, Choi YL, Bae DS (2009) Atypical Leiomyomas of the uterus with long-term follow-up after myomectomy with immunohistochemical analysis for p16INK4A, p53, Ki-67, estrogen receptors, and progesterone receptors. Int J Gynecol Pathol 28: 529-534. Link: https://goo.gl/lV7Bap
Kurman RJ, Norris HJ (1976) Mesenchymal tumors of the uterus. VI. Epithelioid smooth muscle tumors including leiomyoblastoma and clear-cell leiomyoma: a clinical and pathologic analysis of 26 cases. Cancer 37: 1853-1865 Link: https://goo.gl/mp273v
Seed AS, Hanaa B, Faisal AS, Naila AM (2006) Cotyledonoid dissecting leiomyoma of the uterus: a case report of a benign uterine tumor with sarcoma like gross appearance and review of literature. Int J Gynecol Pathol 25: 262-267 Link: https://goo.gl/vmY6Le
Quade BJ, Wang TY, Sornberger K, Dal Cin P, Mutter GL, et al. (2004) Molecular pathogenesis of uterine smooth muscle tumors form transcriptional profiling. Genes Chromosomes Cancer 40: 97-108 Link: https://goo.gl/67Ao7l
Fletcher JA, Morton CC, Pavelka K, Lage JM (1990) Chromosome aberrations in uterine smooth muscle tumors: potential diagnostic relevance of cytogenetic instability. Cancer Res 50: 4092-4097 Link: https://goo.gl/gGm61n
Yanai H, Wani Y, Notohara K, Takada S, Yoshino T (2010) Uterine leiomyosarcoma arising in leiomyoma: Clinicopathological study of four cases and literature review. Pathol Int 60: 506-509. Link: https://goo.gl/z1sAoW
Vecchio R, Leanza V, Genovese F, Accardi M, Gelardi V, et al. (2009) Conservative laparoscopic treatment of a benign giant ovarian cyst in a young woman. J Laparoendosc Adv Surg Tech A 19: 647-648. Link: https://goo.gl/b2oxd8