Case report: Acute Kidney Injury, Liver impairment, Severe Anemia in a child with Malaria and Hyperparasitaemia

Main Article Content

Harshil Gumasana*
Walter Otieno

Abstract

Severe Malaria is a medical emergency mainly because of its rapid progression to complications and death if not promptly and adequately treated. In 2018 WHO put the incidence of P. falciparum Malaria in the African region to be around 99.7%.


We present a case where a boy who presented with high grade fever, prostration, and jaundice. On investigation he was found to have parasitemia of 35%, met multiple criteria for Severe Malaria namely: Hyper-parasitemia, Thrombocytopenia, Anemia and Metabolic acidosis. The child was treated with I.V. Artesunate and I.V. Antibiotics, developed AKI (Acute kidney injury) during the hospital stay necessitating multiple dialysis sessions before making a complete recovery. This is a rare case in several aspects as discussed below.

Downloads

Download data is not yet available.

Article Details

Gumasana, H., & Otieno, W. (2021). Case report: Acute Kidney Injury, Liver impairment, Severe Anemia in a child with Malaria and Hyperparasitaemia. Global Journal of Medical and Clinical Case Reports, 8(1), 001–004. https://doi.org/10.17352/2455-5282.000116
Case Reports

Copyright (c) 2021 Gumasana H, et al.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Licensing and protecting the author rights is the central aim and core of the publishing business. Peertechz dedicates itself in making it easier for people to share and build upon the work of others while maintaining consistency with the rules of copyright. Peertechz licensing terms are formulated to facilitate reuse of the manuscripts published in journals to take maximum advantage of Open Access publication and for the purpose of disseminating knowledge.

We support 'libre' open access, which defines Open Access in true terms as free of charge online access along with usage rights. The usage rights are granted through the use of specific Creative Commons license.

Peertechz accomplice with- [CC BY 4.0]

Explanation

'CC' stands for Creative Commons license. 'BY' symbolizes that users have provided attribution to the creator that the published manuscripts can be used or shared. This license allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author.

Please take in notification that Creative Commons user licenses are non-revocable. We recommend authors to check if their funding body requires a specific license.

With this license, the authors are allowed that after publishing with Peertechz, they can share their research by posting a free draft copy of their article to any repository or website.
'CC BY' license observance:

License Name

Permission to read and download

Permission to display in a repository

Permission to translate

Commercial uses of manuscript

CC BY 4.0

Yes

Yes

Yes

Yes

The authors please note that Creative Commons license is focused on making creative works available for discovery and reuse. Creative Commons licenses provide an alternative to standard copyrights, allowing authors to specify ways that their works can be used without having to grant permission for each individual request. Others who want to reserve all of their rights under copyright law should not use CC licenses.

Shanks GD (2017) The multifactorial epidemiology of blackwater fever. Am J Trop Med Hyg 97: 1804-1807. Link: https://bit.ly/35PqlcY

Daubrey-Potey T, Die-Kacou H, Kamagate M, Vamy M, Balayssac E, et al. (2004) Blackwater fever during antimalarial treatment in Abidjan (West Africa): report of 41 cases. Bull Soc Pathol Exot 97: 325–328. Link: https://bit.ly/39F33HK

Mahamadou D, Hassane DM, Zeinabou MTM, Aboubacar I, Osseini A, et al. (2019) A Report of Four Cases of Blackwater Fever after Quinine Treatment at Zinder National Hospital, Niger Republic. Case Rep Infect Dis 2019: 2346087. Link: https://bit.ly/2LW5u0q

Van den Ende J, Verstraeten T, Coppens G, Van Haegenborgh T, Depraetere K, et al. (1998) Recurrence of blackwater fever: triggering of relapses by different antimalarials. Trop Med Int Health 3: 632–639. Link: https://bit.ly/3oYCOme

Mérat S, Lambert E, Vincenti-Rouquette I, Gidenne S, Rousseau JM, et al. (2003) Case report: combination artemether-lumefantrine and haemolytic anaemia following a malarial attack. Trans R Soc Trop Med Hyg 97: 433-434. Link: https://bit.ly/39EIYBr

Madhuri MS, Elavarasan K, Benjamin VP, Sridhar M, Natarajan S, et al. (2018) Falciparum malaria complicated by black water fever. Journal of Clinical and Scientific Research 7: 187-188. Link: https://bit.ly/2LY4N6M

Olupot-Olupot P, Engoru C, Uyoga S, Muhindo R, Macharia A, et al. (2017) High frequency of blackwater fever among children presenting to hospital with severe febrile illnesses in eastern Uganda. Clin Infect Dis 64: 939-946. Link: https://bit.ly/35QfXBy

Koopsman LC, van Wolfswinkel ME, Hesselink DA, Hoorn EJ, et al. (2015) Acute kidney injury in imported Plasmodium falciparum malaria. Malar J 14: 523. Link: https://bit.ly/3sxwT9L

Bodi JM, Nsibu CN, Longenge RL, Aloni MN, Akilimali PZ, et al.(2013) Blackwater fever in Congolese children: a report of clinical, laboratory features and risk factors. Malar J 12: 205. Link: https://bit.ly/3ikkIbK

Gobbi F, Audagnotto S, Trentini L, Nkurunziza I, Corachan M, et al. (2005) Blackwater fever in children, Burundi. Emerg Infect Dis 11: 1118-1120. Link: https://bit.ly/38R9VCM

Viriyavejakul P, Khachonsaksumet V, Punsawad C (2014) Liver changes in severe Plasmodium falciparum malaria: histopathology, apoptosis and nuclear factor kappa B expression. Malar J 13: 106. Link: https://bit.ly/2XPE139