Complete response of merkel cell carcinoma with brain metastases to pembrolizumab and radiotherapy: A case report
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Albores‐Saavedra J, Batich K, Chable-Montero F, Sagy N, Schwartz AM, et al. (2010) Merkel cell carcinoma demographics, morphology, and survival based on 3870 cases: a population based study. J Cutan Pathol 37: 20-27. Link: https://bit.ly/3wTiRRf
Iyer JG, Blom A, Doumani R, Lewis C, Tarabadkar ES, et al. (2014) Response rate and durability of chemotherapy for metastatic Merkel cell carcinoma among 62 patients. American Society of Clinical Oncology 32. Link: https://bit.ly/2RjUSeU
Tai PT, Yu E, Winquist E, Hammond A, Stitt L, et al. (2000) Chemotherapy in neuroendocrine/Merkel cell carcinoma of the skin: case series and review of 204 cases. J Clin Oncol 18: 2493-2499. Link: https://bit.ly/3pe9FUM
Iyer JG, Afanasiev OK, McClurkan C, Paulson K, Nagase K, et al. (2011) Merkel cell polyomavirus-specific CD8+ and CD4+ T-cell responses identified in Merkel cell carcinomas and blood. Clin Cancer Res 17: 6671-6680. Link: https://bit.ly/3uMKPMQ
Afanasiev OK, Yelistratova L, Miller N, Nagase K, Paulson K, et al. (2013) Merkel polyomavirus-specific T cells fluctuate with merkel cell carcinoma burden and express therapeutically targetable PD-1 and Tim-3 exhaustion markers. Clin Cancer Res 19: 5351-5360. Link: https://bit.ly/3vQ9fXa
Paulson KG, Carter JJ, Johnson LG , Cahill KW , Iyer JG ,et al. (2010) Antibodies to merkel cell polyomavirus T antigen oncoproteins reflect tumor burden in merkel cell carcinoma patients. Cancer Res 70: 388-8397. Link: https://bit.ly/2RhSqpf
Goh G, Walradt T, Markarov V, Blom A, Riaz N, et al. (2016) Mutational landscape of MCPyV-positive and MCPyV-negative Merkel cell carcinomas with implications for immunotherapy. Oncotarget 7: 3403. Link: https://bit.ly/3phwirB
Lipson EJ, Vincent JG, Loyo M, Kagohara LT, Luber BS, et al. (2013) PD-L1 expression in the merkel cell carcinoma microenvironment: association with inflammation, merkel cell polyomavirus, and overall survival. Cancer Immunol Res 1: 54-63. Link: https://bit.ly/3ikZ7Si
Terheyden P, Becker JC (2017) New developments in the biology and the treatment of metastatic Merkel cell carcinoma. Curr Opin Oncol 29: 221-226. Link: https://bit.ly/3pe7NLZ
Nghiem PT, Bhatia S, Lipson EJ, Kudchadkar RR, Miller NJ, et al. (2016) PD-1 blockade with pembrolizumab in advanced Merkel-cell carcinoma. N Engl J Med 374: 2542-2552. Link: https://bit.ly/3cduD14
Kaufman HL, Russell J, Hamid O, Bhatia S, Terheyden P, et al. (2016) Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: a multicentre, single-group, open-label, phase 2 trial. Lancet Oncology 17: 1374-1385. Link: https://bit.ly/3pi35fX
Lebbe C, Becker JC, Grob JJ, Malvehy J, Del Marmol V, et al. (2015) Diagnosis and treatment of Merkel cell carcinoma. European consensus-based interdisciplinary guideline. Eur J Cancer 51: 2396-2403. Link: https://bit.ly/3iih7wL
Lemos BD, Storer BE, Iyer JG , Phillips JL, Bichakjian CK, et al. (2010) Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging system. J Am Acad Dermatol 63: 751-761. Link: https://bit.ly/34HaWub
What does Cancer Genome Interpreter do?. Link: https://bit.ly/3wU3aJG
Niessner H, Forschner A, Klumpp B, Honegger JB, Witte M, et al. (2013) Targeting hyperactivation of the AKT survival pathway to overcome therapy resistance of melanoma brain metastases. Cancer Med 2: 76-85. Link: https://bit.ly/3wShSAD
Ajithkumar T, Parkinson C, Fife K, Corrie P, Jefferies S, et al. (2015) Evolving treatment options for melanoma brain metastases. Lancet Oncol 16: e486-e497. Link: https://bit.ly/3g9MzLb
Sharabi AB, Nirschl CJ, Kochel CM, Nirschl TR, Francica BJ, et al. (2015) Stereotactic Radiation Therapy Augments Antigen-Specific PD-1–Mediated Antitumor Immune Responses via Cross-Presentation of Tumor Antigen. Cancer Immunol Res 3: 345-355. Link: https://bit.ly/2RXIykZ